![]() ![]() Post-RYGB, 49 proteins were returned to normal levels after surgery. ![]() Of these, 395 proteins were significantly altered in obesity before surgery, and 280 proteins differed significantly post-RYGB. Proteomic analysis identified 2,877 quantifiable proteins. 35.3 ± 1.8 kg/m 2) were demonstrated in the pre- versus post-RYGB, both P < 0.05. Significant improvements in fasting plasma glucose (104.2 ± 7.8 vs. We performed quantitative mass spectrometry and microarray analyses on protein and RNA isolated from the muscle biopsies. Four age-matched (48.5 ± 4.7 years) lean (BMI <25 kg/m 2) females served as control subjects. Basal muscle biopsies were obtained from seven obese (BMI >40 kg/m 2) female subjects (45.1 ± 3.6 years) pre- and 3 months post-RYGB, and euglycemic-hyperinsulinemic clamps were used to assess insulin sensitivity. Therefore, the aim of our study was to investigate the role of obesity and RYGB on the human skeletal muscle proteome. The mechanisms of metabolic improvements after Roux-en-Y gastric bypass (RYGB) surgery are not entirely clear. ![]()
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